Safety: Generally considered safe when taken in recommended dosages.The body produces vitamin D3 naturally when the skin is exposed to sunlight, but it can also be obtained through dietary sources and nutritional supplements. Excessive intake can lead to vitamin D toxicity, also known as hypervitaminosis D. This condition results from high doses of vitamin D supplements, not from dietary sources or sun exposure. Vitamin D toxicity can cause a buildup of calcium in the blood (hypercalcemia), leading to nausea, vomiting, weakness, frequent urination, kidney problems, and, in severe cases, calcium stones and cardiovascular issues.

ITP : Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

‍

Some studies and publications: 

• Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1 https://www.cell.com/cell-reports/fulltext/S2211-1247(16)31362-6
• Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer's Disease
•  https://pubmed.ncbi.nlm.nih.gov/29318446/
• Vitamin D in physiological and pathological aging: Lesson from centenarians https://pubmed.ncbi.nlm.nih.gov/31654261/
• Santa, K.; Kumazawa, Y.; Watanabe, K.; Nagaoka, I. The Potential Use of Vitamin D3 and Phytochemicals for Their Anti-Ageing Effects. Int. J. Mol. Sci. 2024, 25, 2125. https://doi.org/10.3390/ijms25042125

‍

Overview: Essential for bone and heart health, immune function, and a range of other physiological effects. Avoiding deficiency, which is common in adults, is the approach for healthspan. Sometimes and in some latitudes, the amount of vitamin D the body can produce is simply not enough to reach optimal levels.

What kind of substance is it: Vitamin D3, also known as cholecalciferol, is a fat-soluble type of vitamin D. Vitamin D3 is one of the two primary forms of vitamin D; the other is vitamin D2 (ergocalciferol). Vitamin D3 is produced naturally in the skin as a response to sunlight (specifically UVB radiation) and is also found in certain animal-based foods such as fish oil, fatty fish, liver, egg yolks, and in fortified foods and dietary supplements. 

Vitamin D2 is primarily obtained from plant sources and fortified foods. Of the two, vitamin D3 is often considered more effective at raising and maintaining overall vitamin D levels in the blood.

‍

‍Other related: Magnesium, vitamin K2, omega3