Quick facts

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Safety: Urolithin A is generally considered safe for most adults, especially when taken at recommended dosages which typically range from 250mg to 1000mg per day. It has been shown to be well-tolerated in short-term studies. However, it's crucial to consult with a healthcare provider before starting urolithin A, particularly to personalize dosage and monitor for any adverse effects.

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ITP results: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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‍Key trials: 

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An, L.; Lu, Q.; Wang, K.; Wang, Y. Urolithins: A Prospective Alternative against Brain Aging. Nutrients 2023, 15, 3884. https://doi.org/10.3390/nu15183884

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Topical application of Urolithin A slows intrinsic skin aging and protects from UVB-mediated photodamage: Findings from Randomized Clinical Trials

D D’Amico, AM Fouassier, J Faitg, N Hennighausen, M Brandt, D Konstantopoulos, C Rinsch, A Singh

medRxiv 2023.06.16.23291378; doi: https://doi.org/10.1101/2023.06.16.23291378

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https://link.springer.com/article/10.1007/s00223-023-01145-5

Mitophagy Activation by Urolithin A to Target Muscle Aging

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Some studies and publications: 

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Kothe B, Klein S, Petrosky SN. Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. Cureus. 2023 Jul 27;15(7):e42550. doi: 10.7759/cureus.42550. PMID: 37637627; PMCID: PMC10460156.

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https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00118-0?dgcid=raven_jbs_aip_email

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

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https://hillblomcenter.ucsf.edu/sites/hillblomcenter.ucsf.edu/files/10.17.16%20Y.Wei_.pdf

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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Overview: Given its role in mitophagy, it has been studied for potential anti-aging effects (improved muscle function and enhanced mitochondrial health).

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Type of substance: Produced by bacteria in the gut microbiome, urolithin A is a postbiotic that is synthesized after eating certain foods high in polyphenols. Postbiotics are by-products from the gut that can act as health-promoting compounds.

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Other related: Glutathione, Coenzime Q10

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