Quick facts

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Safety: TMG (Trimethylglycine), also known as betaine, is generally considered safe when consumed in moderate amounts and is commonly used in supplements to support liver function, healthy homocysteine levels, and cellular replication. However, as with any supplement, it's important to consult with a healthcare professional before beginning use, especially for individuals with pre-existing health conditions or those taking other medications.

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ITP results: Glycine alone had positive results

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Olthof MR, van Vliet T, Boelsma E, Verhoef P. Low dose betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr. 2003 Dec;133(12):4135-8. doi: 10.1093/jn/133.12.4135. PMID: 14652361.

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Some studies and publications: 

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Arumugam MK, Paal MC, Donohue TM Jr, Ganesan M, Osna NA, Kharbanda KK. Beneficial Effects of Betaine: A Comprehensive Review. Biology (Basel). 2021 May 22;10(6):456. doi: 10.3390/biology10060456. PMID: 34067313; PMCID: PMC8224793.

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Overview: TMG is involved in a process called methylation, which is crucial for many bodily functions including DNA repair, detoxification, and cellular energy production. It’s often taken together with NMN to provide more methyl groups.  

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Type of substance:  Also known as betaine, it is a compound that occurs naturally in the body and is also found in foods. 

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Other related: Nicotinamide mononucleotide (NMN), nicotinamide riboside (NR)