Quick facts

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Safety: Resveratrol, a compound found in red wine, grapes, and several other foods, is generally considered safe when taken as a supplement in moderate amounts.

ITP results:Negative

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Ramírez-Garza SL, Laveriano-Santos EP, Marhuenda-Muñoz M, Storniolo CE, Tresserra-Rimbau A, Vallverdú-Queralt A, Lamuela-Raventós RM. Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients. 2018 Dec 3;10(12):1892. doi: 10.3390/nu10121892. PMID: 30513922; PMCID: PMC6317057.

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Zhou DD, Luo M, Huang SY, Saimaiti A, Shang A, Gan RY, Li HB. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxid Med Cell Longev. 2021 Jul 11;2021:9932218. doi: 10.1155/2021/9932218. PMID: 34336123; PMCID: PMC8289612.

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Some studies and publications: 

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Li-Xue Zhang, Chang-Xing Li, Mohib Ullah Kakar, Muhammad Sajjad Khan, Pei-Feng Wu, Rai Muhammad Amir, Dong-Fang Dai, Muhammad Naveed, Qin-Yuan Li, Muhammad Saeed, Ji-Qiang Shen, Shahid Ali Rajput, Jian-Hua Li,

Resveratrol (RV): A pharmacological review and call for further research,

Biomedicine & Pharmacotherapy,

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Islam MS, Jin YY, Chung HJ, Kim HJ, Baek SH, Hong ST. Effect of the Resveratrol Rice DJ526 on Longevity. Nutrients. 2019 Aug 5;11(8):1804. doi: 10.3390/nu11081804. PMID: 31387244; PMCID: PMC6723356.

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Khushwant S. Bhullar, Basil P. Hubbard,

Lifespan and healthspan extension by resveratrol,

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,

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Also check https://sinclair.hms.harvard.edu/publications for extensive work by David Sinclair on Resveratrol

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Overview: A naturally occurring polyphenol (phitoalexin), it acts like a sirtuin promoter and mimics calorie restriction. However, bioavailability in humans is limited (pterostilbene seems to be better) and positive impact on lifespan results are difficult to replicate.

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Type of substance: Resveratrol is a type of natural phenol and a phytoalexin, a class of compounds produced by plants in response to injury or when under attack by pathogens such as bacteria or fungi. It's found in the skin of grapes, berries, and peanuts, and has been widely studied for its potential health benefits, including anti-inflammatory, antioxidant, and cardioprotective properties.

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Other related: Pterostilbene, Quercetin, Fisetin

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