Quick facts

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Safety: Quercetin is generally considered safe for most people when consumed in the amounts typically found in foods. As a supplement, it's also deemed safe for short-term use in appropriate doses. However, potential side effects can include headaches and upset stomach. Long-term safety data is limited.

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ITP results: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Some trials and publications correspond to the Quercetin+Dasatinib combination. Dasatinib is a prescription drug being studied off-label for longevity purposes, often if not always paired with quercetin.

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https://classic.clinicaltrials.gov/ct2/show/NCT04946383

Safety and Effectivness of Quercetin & Dasatinib on Epigenetic Aging

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Islam MT, Tuday E, Allen S, Kim J, Trott DW, Holland WL, Donato AJ, Lesniewski LA. Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age. Aging Cell. 2023 Feb;22(2):e13767. doi: 10.1111/acel.13767. Epub 2023 Jan 13. PMID: 36637079; PMCID: PMC9924942.

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Erin O. Wissler Gerdes, Avanish Misra, Jair Machado Espindola Netto, Tamar Tchkonia, James L. Kirkland,

Strategies for late phase preclinical and early clinical trials of senolytics,

Mechanisms of Ageing and Development

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Some studies and publications: 

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Deepika, Maurya PK. Health Benefits of Quercetin in Age-Related Diseases. Molecules. 2022 Apr 13;27(8):2498. doi: 10.3390/molecules27082498. PMID: 35458696; PMCID: PMC9032170.

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Mirza, M.A.; Mahmood, S.; Hilles, A.R.; Ali, A.; Khan, M.Z.; Zaidi, S.A.A.; Iqbal, Z.; Ge, Y. Quercetin as a Therapeutic Product: Evaluation of Its Pharmacological Action and Clinical Applications—A Review. Pharmaceuticals 2023

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Cui Z, Zhao X, Amevor FK, Du X, Wang Y, Li D, Shu G, Tian Y, Zhao X. Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism. Front Immunol. 2022 Jul 22;13:943321. doi: 10.3389/fimmu.2022.943321. PMID: 35935939; PMCID: PMC9355713.

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Overview: Quercetin is studied for longevity due to its potent antioxidant and anti-inflammatory effects. It's believed to help reduce age-related disease risk by combating oxidative stress and inflammation, key factors in the aging process. Quercetin also influences cellular mechanisms related to lifespan extension, such as sirtuin activation and autophagy, processes important for cellular repair, maintenance, and function.

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What kind of substance is it: Quercetin is a flavonoid, which is a type of plant pigment with antioxidant and anti-inflammatory properties. It is naturally found in various fruits, vegetables, seeds, and grains.

‍Other related: Pterostilbene, Resveratrol, Fisetin