Quick facts

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Safety: Pterostilbene, a compound found in blueberries and related to resveratrol, is generally considered safe when taken in amounts found in food. As a supplement, it's used for its potential antioxidant and anti-inflammatory benefits. However, long-term safety data and comprehensive studies on its effects and optimal dosages in humans are limited. 

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ITP results: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Daniel M. Riche, Krista D. Riche, Chad T. Blackshear, Corey L. McEwen, Justin J. Sherman, Marion R. Wofford, Michael E. Griswold, "Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial", Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 459165, 8 pages, 2014. https://doi.org/10.1155/2014/459165

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Dellinger, R.W., Santos, S.R., Morris, M. et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging Mech Dis 3, 17 (2017). https://doi.org/10.1038/s41514-017-0016-9

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Some studies and publications: 

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https://iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.1400 Effect of resveratrol and pterostilbene on aging and longevity

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Nagarajan S, Mohandas S, Ganesan K, Xu B, Ramkumar KM. New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects. Molecules. 2022 Sep 25;27(19):6316. doi: 10.3390/molecules27196316. PMID: 36234852; PMCID: PMC9571692.

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McCormack D, McFadden D. A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev. 2013;2013:575482. doi: 10.1155/2013/575482. Epub 2013 Apr 4. PMID: 23691264; PMCID: PMC3649683.

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Overview: Natural dietary compound and polyphenol analog to resveratrol, with three methyl groups added that provide better bioavailability.

Type of substance: Polyphenol analog to resveratrol

‍Other related: Resveratrol

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