Safety: For most people, taking omega-3 supplements is considered safe when used in appropriate amounts. However, there are some considerations:

• Dosage: High doses of omega-3 supplements can lead to blood thinning and increase the risk of bleeding, particularly if you’re also taking blood-thinners. It's important to stick to recommended dosages and consult with a healthcare provider if you're considering higher doses.
• Purity: Some omega-3 supplements derived from fish oil may contain contaminants like mercury or PCBs. To minimize risk, choose high-quality supplements that have been tested and certified by reputable third-party organizations.
• Interactions: Omega-3 supplements can interact with certain medications, including blood thinners and drugs for hypertension. If you're taking any medications, consult with a healthcare provider before starting omega-3 supplements.
• Side Effects: Some people may experience side effects from omega-3 supplements, such as fishy aftertaste, gastrointestinal discomfort, or nausea. These side effects can often be minimized by taking supplements with meals or choosing high-quality, clean products.
• Health conditions: If you have specific health conditions, particularly those that might be affected by increased bleeding risk, it's important to talk to a healthcare professional before starting omega-3 supplements.

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ITP: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Some studies and publications: 

(studies on omega3 benefits are countless but these link it to longevity, just a sample)

Vijay Karam Singh, Ronald Ross Watson, Enhanced Longevity and Role of Omega-3 Fatty Acids

Zhu Y, Ferrara A, Forman M R. Omega 3 polyunsaturated fatty acids and healthy ageing

Champigny, C.M.; Cormier, R.P.J.; Simard, C.J.; St-Coeur, P.-D.; Fortin, S.; Pichaud, N. Omega-3 Monoacylglyceride Effects on Longevity, Mitochondrial Metabolism and Oxidative Stress: Insights from Drosophila melanogaster.

de Magalhães JP, Müller M, Rainger GE, Steegenga W. Fish oil supplements, longevity and aging. Aging

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Overview: Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), offer numerous health benefits for heart, mental, eye, bone, skin, and brain health; chronic inflammation reduction; fighting autoimmune diseases; and supporting quality sleep. 

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Type of substance: Omega-3 fatty acids are a type of polyunsaturated fat, which are considered essential since the body cannot produce them on its own; they must be obtained through the diet. 

There are three main types of omega-3 fatty acids:

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• Alpha-linolenic acid (ALA): This is the most common omega-3 fatty acid in the diet. ALA is mostly found in plant foods, such as flaxseeds, chia seeds, hemp seeds, walnuts, and their oils. The body can convert small amounts of ALA into EPA and DHA, but the process is not very efficient.
• Eicosapentaenoic acid (EPA): EPA is found primarily in fish and seafood, including fatty fish like salmon, mackerel, and sardines. It is known for its anti-inflammatory effects and its role in heart health.
• Docosahexaenoic acid (DHA): DHA is also found mainly in fatty fish and sea algae. It is a crucial component of the brain and retina, and adequate intake of DHA is important for brain development and function.

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Other related: D3 vitamin, K2 vitamin, magnesium

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