Quick facts

Safety: Research and clinical trials have generally shown that NMN is safe for most people when taken at recommended doses. Studies have used a wide range of doses, with many finding it well-tolerated up to 1,000 mg or more per day. 

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ITP results: not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

Fukamizu, Y., Uchida, Y., Shigekawa, A. et al. Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women. Sci Rep

Only evaluated safety and for a short period

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https://www.nature.com/articles/s41467-018-03421-7

oral supplementation with either of the NAD+ metabolites, nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), increases levels of NAD+ and improves multiple physiological functions in animal models

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https://www.sciencedirect.com/science/article/pii/S0047637421001391?via%3Dihub

Two precursors that have been extensively studied are NMN and NR. Preclinical studies using NMN have shown broad health benefits, covering the reversal of vascular dysfunction and oxidative stress, suppression of age-associated body weight gain, promotion of physical activity, improvement of insulin sensitivity, amelioration of the plasma lipid profile and mitigation of other age-associated phenotypes in mice (de Picciotto et al., 2016; Mills et al., 2016; Yoshino et al., 2011). NMN treatment leads to increased longevity and improved health in xpa-1 nematodes (Fang et al., 2014). In a C. elegans model of XPA, NMN was shown to extend lifespan by 117 % compared to control worms (Fang et al., 2014).

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Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188.

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Some studies and publications: 

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https://www.nature.com/articles/d42473-022-00002-7 summarizes some experiences and focus on human efficacy

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i X, Yang H, Jin H, Turkez H, Ozturk G, Doganay HL, Zhang C, Nielsen J, Uhlén M, Borén J, Mardinoglu A. The acute effect of different NAD+ precursors included in the combined metabolic activators. Free Radic Biol Med. 2023 Aug 20;205:77-89. doi: 10.1016/j.freeradbiomed.2023.05.032. Epub 2023 Jun 2. PMID: 37271226.

“CMAs with Nam, NMN as well as NR can be administered for boosting NAD+ levels to improve altered metabolic conditions”

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Overview: NMN is studied for longevity as it is a precursor to NAD+, a crucial coenzyme for various cellular processes, including metabolism, DNA repair, and energy production. As organisms age, NAD+ levels decline, contributing to age-related diseases and metabolic disorders. Research on NMN aims to reverse these declines, thereby potentially extending healthspan and lifespan.

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Type of substance: Nucleotide derived from ribose and nicotinamide. It's a precursor to nicotinamide adenine dinucleotide (NAD+), an essential molecule found in all living cells. NR converts to NMN which in turn is a precursor to NAD, which is why some believe it’s a type of “shortcut.” However, considerably more research has been carried out on NR.

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Other related: Nicotinamide Riboside (NR)

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