Quick facts

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Safety: Taking glutathione as a supplement is generally considered safe for most people. Glutathione is a powerful antioxidant produced naturally by the body, playing a key role in reducing oxidative stress, supporting the immune system, and detoxifying harmful substances. However, the effectiveness of oral supplementation may vary due to various factors, such as poor absorption in the digestive tract. 

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ITP results: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. doi: 10.1089/acm.2010.0716. PMID: 21875351; PMCID: PMC3162377.

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Kalamkar S, Acharya J, Kolappurath Madathil A, Gajjar V, Divate U, Karandikar-Iyer S, Goel P, Ghaskadbi S. Randomized Clinical Trial of How Long-Term Glutathione Supplementation Offers Protection from Oxidative Damage and Improves HbA1c in Elderly Type 2 Diabetic Patients. Antioxidants (Basel). 2022 May 23;11(5):1026. doi: 10.3390/antiox11051026. PMID: 35624890; PMCID: PMC9137531.

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Some studies and publications: 

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Pizzorno J. Glutathione! Integr Med (Encinitas). 2014 Feb;13(1):8-12. PMID: 26770075; PMCID: PMC4684116.

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A A Romero-Haro, J Figuerola, C Alonso-Alvarez, Low Antioxidant Glutathione Levels Lead to Longer Telomeres: A Sex-Specific Link to Longevity?, Integrative Organismal Biology, Volume 5, Issue 1, 2023, obad034, https://doi.org/10.1093/iob/obad034

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https://link.springer.com/article/10.1007/BF02434082

Glutathione, oxidative stress and aging (1996!)

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Overview: Glutathione is studied for longevity due to its potent antioxidant properties, helping to combat oxidative stress, which is linked to aging and many chronic diseases. It also supports detoxification processes and immune system health, potentially contributing to a longer, healthier life.

Liposomal formulas are best to maximize bioavailability, as nano-liposomes are best absorbed in the small intestine. Also considering quality of the supplement is recommended as always.

Type of substance: Tripeptide substance composed largely of three amino acids: glutamine, glycine, and cysteine. Glutathione is present in almost every cell in the body, though levels lower with age. A potent antioxidant, it supports immune function and tissue repair. Production can be boosted by eating certain sulfur-rich foods or whey protein.

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Other related: Urolithin, Coenzime Q10

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