Quick facts

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Safety: Glucosamine is generally considered safe when taken as a supplement by most people. It's commonly used to support joint health and may help with the symptoms of osteoarthritis. Individuals with shellfish allergies should use caution, as some glucosamine products are derived from shellfish. Those taking certain medications like blood thinners should consult a healthcare professional to avoid potential interactions. As with any supplement, always discuss it with a trusted medical provider.

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‍ITP results: Not included

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Li ZH, Gao X, Chung VC, Zhong WF, Fu Q, Lv YB, Wang ZH, Shen D, Zhang XR, Zhang PD, Li FR, Huang QM, Chen Q, Song WQ, Wu XB, Shi XM, Kraus VB, Yang X, Mao C. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020 Jun;79(6):829-836. doi: 10.1136/annrheumdis-2020-217176. Epub 2020 Apr 6. PMID: 32253185; PMCID: PMC7286049.

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Mark F. McCarty , James H. O'Keefe & James J. DiNicolantonio (2019) Glucosamine for the Treatment of Osteoarthritis: The Time Has Come for Higher-Dose Trials, Journal of Dietary Supplements, 16:2, 179-192, DOI: 10.1080/19390211.2018.1448920

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Some studies and publications: 

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Weimer, S., Priebs, J., Kuhlow, D. et al. D-Glucosamine supplementation extends life span of nematodes and of ageing mice. Nat Commun 5, 3563 (2014). https://doi.org/10.1038/ncomms4563

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So Young Yoon, Vikram P. Narayan,

Genetically predicted glucosamine and longevity: A Mendelian randomization study,

Clinical Nutrition ESPEN

https://www.sciencedirect.com/science/article/abs/pii/S240545772200211X

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Li ZH, Gao X, Chung VC, Zhong WF, Fu Q, Lv YB, Wang ZH, Shen D, Zhang XR, Zhang PD, Li FR, Huang QM, Chen Q, Song WQ, Wu XB, Shi XM, Kraus VB, Yang X, Mao C. Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Ann Rheum Dis. 2020 Jun;79(6):829-836. doi: 10.1136/annrheumdis-2020-217176. Epub 2020 Apr 6. PMID: 32253185; PMCID: PMC7286049.

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Janssens GE, Houtkooper RH. Identification of longevity compounds with minimized probabilities of side effects. Biogerontology. 2020 Dec;21(6):709-719. doi: 10.1007/s10522-020-09887-7. Epub 2020 Jun 19. PMID: 32562114; PMCID: PMC7541369.

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Overview: Its anti-inflammatory and cellular protective properties are being investigated, including N-Acetylglucosamine to manage multiple sclerosis.

‍Type of substance: Glucosamine is a natural compound found in cartilage usually indicated to support joint health. 

‍Other related: Magnesium, Berberine, D3 Vitamin