Quick facts

‍

Safety:Fisetin is generally considered safe when consumed in amounts found in foods. As a supplement, it's considered safe for most people when taken in appropriate doses. However, long-term safety and optimal dosages haven’t been fully established. 

‍

ITP results: Negative

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

‍

Key trials: 

‍

Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI, Pirtskhalava T, Inman CL, McGuckian C, Wade EA, Kato JI, Grassi D, Wentworth M, Burd CE, Arriaga EA, Ladiges WL, Tchkonia T, Kirkland JL, Robbins PD, Niedernhofer LJ. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. 2018 Oct;36:18-28. doi: 10.1016/j.ebiom.2018.09.015. Epub 2018 Sep 29. PMID: 30279143; PMCID: PMC6197652.

‍

https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/mayo-clinic-fisetin

‍

Some studies and publications: 

‍

Huard CA, Gao X, Dey Hazra ME, Dey Hazra RO, Lebsock K, Easley JT, Millett PJ, Huard J. Effects of Fisetin Treatment on Cellular Senescence of Various Tissues and Organs of Old Sheep. Antioxidants (Basel). 2023 Aug 21;12(8):1646. doi: 10.3390/antiox12081646. PMID: 37627641; PMCID: PMC10451965.

‍

https://link.springer.com/article/10.1007/s11130-021-00946-z

Dietary Phytochemicals that Can Extend Longevity by Regulation of Metabolism

‍

https://www.sciencedirect.com/topics/medicine-and-dentistry/fisetin

https://academic.oup.com/stmcls/article/41/7/698/7190776

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells

‍

Overview: Fisetin is being studied for longevity due to its potent senolytic properties, meaning it can target and remove senescent cells that accumulate over time and contribute to aging and age-related diseases. Research suggests fisetin may improve healthspan by reducing inflammation and enhancing tissue function, making it a promising compound in the quest to extend healthy years of life.

‍

Type of substance: Fisetin is a flavonoid, a type of plant compound found naturally in various fruits and vegetables, such as strawberries, apples, and onions.

‍Other related: Pterostilbene, Resveratrol, Quercetin