Ashwagandha (Withania somnifera), a key herb in traditional Ayurvedic medicine, is classified as an adaptogen, meaning it helps the body adapt to stress and maintain balance.

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Ashwagandha (Withania somnifera), a prominent adaptogenic herb in Ayurvedic medicine, has been the subject of various studies exploring its potential impact on longevity and age-related health concerns. Key findings include:

1. Activation of Longevity Pathways

• AMPK Activation and mTOR Inhibition: Withaferin A, a bioactive compound in ashwagandha, has been shown to activate AMP-activated protein kinase (AMPK) and inhibit the mammalian target of rapamycin (mTOR) pathway. This modulation mimics the biochemical effects of calorie restriction, a well-known strategy for promoting longevity.

2. Enhancement of Telomerase Activity

• Telomere Maintenance: Research indicates that human cells treated with KSM-66 ashwagandha root extract exhibit a significant increase in telomerase activity. Telomerase is an enzyme responsible for maintaining telomere length, which is crucial for cellular aging and longevity.

3. Reduction of Age-Related Protein Damage

• Neuroprotective Effects: In animal studies, withaferin A demonstrated a 39% reduction in age-related protein damage in the spinal cord and a 60% reduction in motor neuron cells. Additionally, supplementation extended the lifespan of mice with age-related protein breakdown by 5.6%.

4. Promotion of Autophagy

• Cellular Cleanup: Ashwagandha has been found to promote autophagy, the body's process of clearing out damaged cells and regenerating new ones. This function is vital for maintaining cellular health and longevity.

5. Cognitive Health Support

• Memory and Cognitive Function: Clinical studies have shown that ashwagandha supplementation can improve memory, attention, and information processing speed in adults, suggesting potential benefits in mitigating age-related cognitive decline.

6. Anti-Inflammatory and Antioxidant Properties

• Reduction of Oxidative Stress: Ashwagandha exhibits significant anti-inflammatory and antioxidant effects, which may contribute to its role in promoting healthy aging by reducing oxidative stress and inflammation, both associated with aging and chronic diseases.

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https://lifespa.com/health-topics/aging-longevity/ashwagandha-longevity/

https://xandrolab.com/blog/what-are-the-longevity-benefits-of-taking-ashwagandha

https://pubmed.ncbi.nlm.nih.gov/35873404/

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