Quick facts

Safety: Alpha-lipoic acid is considered potentially safe when taken as directed and used for various health conditions, including weight loss, diabetic nerve pain, and improving skin conditions. ​

However, following dosage guidelines and consulting a healthcare provider before use is essential, particularly for individuals with liver disease, diabetes, thyroid disorders, or those who are pregnant and/or breastfeeding. Side effects may include nausea and skin rash, and it's advised to be cautious of potential interactions with other medications and supplements​.

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ITP results: not tested

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

• Derosa G, D'Angelo A, Preti P, Maffioli P. Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention
• Salehi B, Berkay Yılmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N, Cho WC, Sharifi-Rad J. Insights on the Use of α-Lipoic Acid for Therapeutic Purposes. Biomolecules. 2019

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Some studies and publications: 

• Lipoic Acid Explored As Anti-aging Compound https://www.sciencedaily.com/releases/2007/05/070517130823.htm Researchers said they have identified the mechanism of action of lipoic acid, a remarkable compound that in animal experiments appears to slow down the process of aging, improve blood flow, enhance immune function and perform many other functions.
• Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid. Front Pharmacol. 2011 
• Garcia-Medina JJ, Rubio-Velazquez E, Lopez-Bernal MD, Cobo-Martinez A, Zanon-Moreno V, Pinazo-Duran MD, Del-Rio-Vellosillo M. Glaucoma and Antioxidants: Review and Update. Antioxidants (Basel). 2020

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Overview: Glycemic control and lipid profile improvement through antioxidant properties. Animal model studies have shown that ALA can restore the declining functions of older cells, improve signaling in older blood vessels, delay mitochondrial decay, and restore glutathione production, which declines with age. These functions are critical in combating the effects of aging and maintaining overall health.

Type of substance: Alpha-Lipoic Acid (ALA) is a naturally occurring compound that's considered a powerful antioxidant. It plays a crucial role in the cellular process that metabolizes glucose for energy. ALA is unique because it is both water- and fat-soluble, unlike other antioxidants. This allows ALA to work in every cell or tissue in the body. The body produces ALA in small amounts, but it can also be found in some foods and is also available as a dietary supplement.

‍Other related: coenzime q10, glutathione