Quick facts

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Safety: Alpha-Ketoglutarate (AKG) is considered safe for most people when taken as a dietary supplement within recommended dosages.

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ITP results: In progress

(The Interventions Testing Program (ITP) is a peer-reviewed program designed to identify agents that extend lifespan and healthspan in mice)

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Key trials: 

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Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021 Nov 30;13(22):24485-24499. doi: 10.18632/aging.203736. Epub 2021 Nov 30. PMID: 34847066; PMCID: PMC8660611.

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Sandalova, E., Goh, J., Lim, Z.X. et al. Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)—intervention study protocol. GeroScience 45, 2897–2907 (2023). https://doi.org/10.1007/s11357-023-00813-6

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https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/national-university-of-singapore-alpha-ketoglutarate

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Some studies and publications: 

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Naeini SH, Mavaddatiyan L, Kalkhoran ZR, Taherkhani S, Talkhabi M. Alpha-ketoglutarate as a potent regulator for lifespan and healthspan: Evidences and perspectives. Exp Gerontol. 2023 May;175:112154. doi: 10.1016/j.exger.2023.112154. Epub 2023 Mar 20. PMID: 36934991.

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Asadi Shahmirzadi A, Edgar D, Liao CY, Hsu YM, Lucanic M, Asadi Shahmirzadi A, Wiley CD, Gan G, Kim DE, Kasler HG, Kuehnemann C, Kaplowitz B, Bhaumik D, Riley RR, Kennedy BK, Lithgow GJ. Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice. Cell Metab. 2020 Sep 1;32(3):447-456.e6. doi: 10.1016/j.cmet.2020.08.004. PMID: 32877690; PMCID: PMC8508957.

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Chin, R., Fu, X., Pai, M. et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 510, 397–401 (2014). https://doi.org/10.1038/nature13264

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Overview:AKG is studied for longevity as it plays a key role in the Krebs cycle, an essential part of cellular energy production. Its involvement in energy metabolism and potential to reduce inflammation and oxidative stress suggests it could impact aging processes. It’s a natural compound that works in many pathways in the body, including muscle production and wound healing.

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Type of substance: Alpha-Ketoglutarate (AKG) is a substance that is naturally produced in the human body. It is a key intermediate in the Krebs cycle (also known as the citric acid cycle),  a crucial part of cellular energy production. AKG is involved in amino acid synthesis, energy metabolism, and the regulation of oxidative stress and cellular aging processes.  

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Other related: NR, NMN, Metformin

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